A minimally-invasive serial cerebrospinal fluid sampling model in conscious Göttingen minipigs

Drug concentrations in cerebrospinal fluid (CSF) are typically used as a as a surrogate measure of their availability in the CNS, and CSF penetration in animal studies are used for assessment of CNS drug delivery in early preclinical drug development. The minipig is a valid alternative to dogs and n...

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Detalles Bibliográficos
Autores principales: Bergadano, Alessandra, Amen, Eva Maria, Jacobsen, Björn, Belli, Sara, Vandjour, Anthony, Rapp, Christelle, Senn, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Biological Methods 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706129/
https://www.ncbi.nlm.nih.gov/pubmed/31453257
http://dx.doi.org/10.14440/jbm.2019.265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706129/
https://www.ncbi.nlm.nih.gov/pubmed/31453257
http://dx.doi.org/10.14440/jbm.2019.265

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