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A minimally-invasive serial cerebrospinal fluid sampling model in conscious Göttingen minipigs
Drug concentrations in cerebrospinal fluid (CSF) are typically used as a as a surrogate measure of their availability in the CNS, and CSF penetration in animal studies are used for assessment of CNS drug delivery in early preclinical drug development. The minipig is a valid alternative to dogs and n...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Journal of Biological Methods
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706129/ https://www.ncbi.nlm.nih.gov/pubmed/31453257 http://dx.doi.org/10.14440/jbm.2019.265 |