Cargando…

A single K(+)-binding site in the crystal structure of the gastric proton pump

The gastric proton pump (H(+),K(+)-ATPase), a P-type ATPase responsible for gastric acidification, mediates electro-neutral exchange of H(+) and K(+) coupled with ATP hydrolysis, but with an as yet undetermined transport stoichiometry. Here we show crystal structures at a resolution of 2.5 Å of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamamoto, Kenta, Dubey, Vikas, Irie, Katsumasa, Nakanishi, Hanayo, Khandelia, Himanshu, Fujiyoshi, Yoshinori, Abe, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706254/ https://www.ncbi.nlm.nih.gov/pubmed/31436534 http://dx.doi.org/10.7554/eLife.47701

Ejemplares similares

Serine phosphorylation regulates the P-type potassium pump KdpFABC
por: Sweet, Marie E, et al.
Publicado: (2020)

A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence
por: Shimomura, Takushi, et al.
Publicado: (2020)

Gastric proton pump with two occluded K(+) engineered with sodium pump-mimetic mutations
por: Abe, Kazuhiro, et al.
Publicado: (2021)

K(+) binding and proton redistribution in the E(2)P state of the H(+), K(+)-ATPase
por: Dubey, Vikas, et al.
Publicado: (2018)

Structure and function of H(+)/K(+) pump mutants reveal Na(+)/K(+) pump mechanisms
por: Young, Victoria C., et al.
Publicado: (2022)

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA
por: Fisher, M'Lynn E, et al.
Publicado: (2021)

Proton transfer pathway in anion channelrhodopsin-1
por: Tsujimura, Masaki, et al.
Publicado: (2021)

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
por: Eicher, Thomas, et al.
Publicado: (2014)

Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study
por: Sasaki, Takashi, et al.
Publicado: (2023)

Structural basis of proton translocation and force generation in mitochondrial ATP synthase
por: Klusch, Niklas, et al.
Publicado: (2017)

Crystal structure of a natural light-gated anion channelrhodopsin
por: Li, Hai, et al.
Publicado: (2019)

Wedging open a catalytic site
por: Beuve, Annie
Publicado: (2019)

Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter
por: Bozzi, Aaron T, et al.
Publicado: (2019)

Visualizing formation of the active site in the mitochondrial ribosome
por: Chandrasekaran, Viswanathan, et al.
Publicado: (2021)

A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells
por: Noor, Sina Ibne, et al.
Publicado: (2018)

Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway
por: Chim, Nicholas, et al.
Publicado: (2018)

Diverse nucleosome Site-Selectivity among histone deacetylase complexes
por: Wang, Zhipeng A, et al.
Publicado: (2020)

Cooperation among c-subunits of F(o)F(1)-ATP synthase in rotation-coupled proton translocation
por: Mitome, Noriyo, et al.
Publicado: (2022)

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
por: Uprety, Rajendra, et al.
Publicado: (2021)

Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation
por: Miyazaki, Ryoji, et al.
Publicado: (2020)

Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion
por: Shin, Donghyuk, et al.
Publicado: (2017)

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator
por: Capdevila, Daiana A, et al.
Publicado: (2018)

Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics
por: Mostyn, Shannon N, et al.
Publicado: (2019)

Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau
por: Ma, Xiaojuan, et al.
Publicado: (2020)

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
por: Feilen, Lukas P, et al.
Publicado: (2022)

Anti-diabetic drug binding site in a mammalian K(ATP) channel revealed by Cryo-EM
por: Martin, Gregory M, et al.
Publicado: (2017)

Monitoring site-specific conformational changes in real-time reveals a misfolding mechanism of the prion protein
por: Sengupta, Ishita, et al.
Publicado: (2019)

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues
por: Hall, Kelsi R, et al.
Publicado: (2020)

Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP
por: Hansen, Sarah R, et al.
Publicado: (2022)

Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways
por: Miyazaki, Ryoji, et al.
Publicado: (2021)

Creation of photocyclic vertebrate rhodopsin by single amino acid substitution
por: Sakai, Kazumi, et al.
Publicado: (2022)

The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate
por: Irie, Katsumasa, et al.
Publicado: (2012)

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast
por: Martin-Marcos, Pilar, et al.
Publicado: (2017)

Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide
por: Snapp, Erik Lee, et al.
Publicado: (2017)

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo
por: Röper, Jens-Christian, et al.
Publicado: (2018)

VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells
por: Mohan, Chitra, et al.
Publicado: (2018)

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites
por: Dietzen, Noah M, et al.
Publicado: (2022)

Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane protease SpoIVFB
por: Olenic, Sandra, et al.
Publicado: (2022)

A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation
por: Du, Jiale, et al.
Publicado: (2022)

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets
por: Rodriguez, Kelsie M, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j6v52jjdf6eqr6u6apt2udpmh1