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Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster

BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As abnormal alterations in histone acetylation and methylation sh...

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Detalles Bibliográficos
Autores principales: Park, Sung Yeon, Seo, Jieun, Chun, Yang-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706347/
https://www.ncbi.nlm.nih.gov/pubmed/31436053
http://dx.doi.org/10.3346/jkms.2019.34.e225