Anomalous enhancement of resurgent Na(+) currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia

Inherited erythromelalgia (IEM), caused by mutations in Na(v)1.7 channel is characterized by episodic neuropathic pain triggered especially by warm temperature. However, the mechanism underlying the temperature–dependent episodic attacks of IEM remains elusive. We investigated the electrophysiologic...

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Detalles Bibliográficos
Autores principales: Huang, Chiung-Wei, Lai, Hsing-Jung, Huang, Po-Yuan, Lee, Ming-Jen, Kuo, Chung-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706385/
https://www.ncbi.nlm.nih.gov/pubmed/31439884
http://dx.doi.org/10.1038/s41598-019-48672-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706385/
https://www.ncbi.nlm.nih.gov/pubmed/31439884
http://dx.doi.org/10.1038/s41598-019-48672-6

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