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Nucleosome and ubiquitin position Set2 to methylate H3K36

Histone H3 lysine 36 methylation (H3K36me) is a conserved histone modification deposited by the Set2 methyltransferases. Recent findings show that over-expression or mutation of Set2 enzymes promotes cancer progression, however, mechanisms of H3K36me are poorly understood. Set2 enzymes show spurious...

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Detalles Bibliográficos
Autores principales: Bilokapic, Silvija, Halic, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706414/
https://www.ncbi.nlm.nih.gov/pubmed/31439846
http://dx.doi.org/10.1038/s41467-019-11726-4