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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Pediatric high-grade gliomas are among the deadliest of childhood cancers due to limited knowledge of early driving events in their gliomagenesis and the lack of effective therapies available. In this study, we investigate the oncogenic role of PPM1D, a protein phosphatase often found truncated in p...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706443/ https://www.ncbi.nlm.nih.gov/pubmed/31439867 http://dx.doi.org/10.1038/s41467-019-11732-6 |