Crystal structure and substrate-induced activation of ADAMTS13

Platelet recruitment to sites of blood vessel damage is highly dependent upon von Willebrand factor (VWF). VWF platelet-tethering function is proteolytically regulated by the metalloprotease ADAMTS13. Proteolysis depends upon shear-induced conformational changes in VWF that reveal the A2 domain clea...

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Detalles Bibliográficos
Autores principales: Petri, Anastasis, Kim, Hyo Jung, Xu, Yaoxian, de Groot, Rens, Li, Chan, Vandenbulcke, Aline, Vanhoorelbeke, Karen, Emsley, Jonas, Crawley, James T. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706451/
https://www.ncbi.nlm.nih.gov/pubmed/31439947
http://dx.doi.org/10.1038/s41467-019-11474-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706451/
https://www.ncbi.nlm.nih.gov/pubmed/31439947
http://dx.doi.org/10.1038/s41467-019-11474-5

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