Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma

Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolit...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Jun-ping, Zhu, Zhen-han, Wu, Yue-zhang, Qian, Wen, Li, Zhi-yu, Nishikawa, Miyu, Sakaki, Toshiyuki, Yang, Chang-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706704/
https://www.ncbi.nlm.nih.gov/pubmed/31531047
http://dx.doi.org/10.22037/ijpr.2019.1100641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706704/
https://www.ncbi.nlm.nih.gov/pubmed/31531047
http://dx.doi.org/10.22037/ijpr.2019.1100641

Ejemplares similares