Two-Dimensional Droplet Digital PCR as a Tool for Titration and Integrity Evaluation of Recombinant Adeno-Associated Viral Vectors

Recombinant adeno-associated virus (rAAV) vectors have recently been widely utilized for in in vivo gene therapy. The clinical dose definition of AAV vector requires the exact quantification as starting doses and for dose-escalation studies. Vector genome (vg) copies measured by quantitative PCR (qP...

Descripción completa

Detalles Bibliográficos
Autores principales: Furuta-Hanawa, Birei, Yamaguchi, Teruhide, Uchida, Eriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707039/
https://www.ncbi.nlm.nih.gov/pubmed/31140327
http://dx.doi.org/10.1089/hgtb.2019.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707039/
https://www.ncbi.nlm.nih.gov/pubmed/31140327
http://dx.doi.org/10.1089/hgtb.2019.031

Ejemplares similares