TLR-2 mediated cytosolic-Ca(2+) surge activates ER-stress-superoxide-NO signalosome augmenting TNF-α production leading to apoptosis of Mycobacterium smegmatis-infected fish macrophages

The implications of TLR-2 mediated alterations in cytosolic-Ca(2+)((Ca(2+))(c)) levels in M. smegmatis infections is not well known. Using headkidney macrophages (HKM) from Clarias gariepinus, we observed TLR-2 signalling is required in the phagocytosis of M. smegmatis. M. smegmatis induced caspase-...

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Detalles Bibliográficos
Autores principales: Hussain, Md. Arafat, Datta, Debika, Singh, Rashmi, Kumar, Manmohan, Kumar, Jai, Mazumder, Shibnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707155/
https://www.ncbi.nlm.nih.gov/pubmed/31444398
http://dx.doi.org/10.1038/s41598-019-48847-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707155/
https://www.ncbi.nlm.nih.gov/pubmed/31444398
http://dx.doi.org/10.1038/s41598-019-48847-1

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