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GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout
Knockout of phosphatase and tensin homolog (PTEN(−/−)) is neuroprotective and promotes axon regeneration in mature neurons. Elevation of mTOR activity in injured neurons has been proposed as the primary underlying mechanism. Here we demonstrate that PTEN(−/−) also abrogates the inhibitory activity o...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707209/ https://www.ncbi.nlm.nih.gov/pubmed/31453382 http://dx.doi.org/10.1038/s42003-019-0524-1 |