Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

E-cadherin (CDH1) is a master regulator of epithelial cell adherence junctions and a well-established tumor suppressor in Invasive Lobular Carcinoma (ILC). Intriguingly, somatic inactivation of E-cadherin alone in mouse mammary epithelial cells (MMECs) is insufficient to induce tumor formation. Here...

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Detalles Bibliográficos
Autores principales: Schipper, Koen, Seinstra, Danielle, Paulien Drenth, Anne, van der Burg, Eline, Ramovs, Veronika, Sonnenberg, Arnoud, van Rheenen, Jacco, Nethe, Micha, Jonkers, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707221/
https://www.ncbi.nlm.nih.gov/pubmed/31444332
http://dx.doi.org/10.1038/s41467-019-11716-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707221/
https://www.ncbi.nlm.nih.gov/pubmed/31444332
http://dx.doi.org/10.1038/s41467-019-11716-6

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