Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin

A pre-existing, allosteric equilibrium between closed (E*) and open (E) conformations of the active site influences the level of activity in the trypsin fold and defines ligand binding according to the mechanism of conformational selection. Using the clotting protease thrombin as a model system, we...

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Detalles Bibliográficos
Autores principales: Pelc, Leslie A., Koester, Sarah K., Chen, Zhiwei, Gistover, Noah E., Di Cera, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707225/
https://www.ncbi.nlm.nih.gov/pubmed/31444378
http://dx.doi.org/10.1038/s41598-019-48839-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707225/
https://www.ncbi.nlm.nih.gov/pubmed/31444378
http://dx.doi.org/10.1038/s41598-019-48839-1

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