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Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin
A pre-existing, allosteric equilibrium between closed (E*) and open (E) conformations of the active site influences the level of activity in the trypsin fold and defines ligand binding according to the mechanism of conformational selection. Using the clotting protease thrombin as a model system, we...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707225/ https://www.ncbi.nlm.nih.gov/pubmed/31444378 http://dx.doi.org/10.1038/s41598-019-48839-1 |