Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we present structures of the neddylated and deneddylated CSN-CRL2 complexes by combining single-par...

Descripción completa

Detalles Bibliográficos
Autores principales: Faull, Sarah V., Lau, Andy M. C., Martens, Chloe, Ahdash, Zainab, Hansen, Kjetil, Yebenes, Hugo, Schmidt, Carla, Beuron, Fabienne, Cronin, Nora B., Morris, Edward P., Politis, Argyris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707232/
https://www.ncbi.nlm.nih.gov/pubmed/31444342
http://dx.doi.org/10.1038/s41467-019-11772-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707232/
https://www.ncbi.nlm.nih.gov/pubmed/31444342
http://dx.doi.org/10.1038/s41467-019-11772-y

Ejemplares similares