Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis

Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is the most abundant protein in normal urine. Defective uromodulin processing is associated with various kidney disorders. The luminal release and subsequent polymerization...

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Detalles Bibliográficos
Autores principales: Olinger, Eric, Lake, Jennifer, Sheehan, Susan, Schiano, Guglielmo, Takata, Tomoaki, Tokonami, Natsuko, Debaix, Huguette, Consolato, Francesco, Rampoldi, Luca, Korstanje, Ron, Devuyst, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707305/
https://www.ncbi.nlm.nih.gov/pubmed/31444371
http://dx.doi.org/10.1038/s41598-019-48300-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707305/
https://www.ncbi.nlm.nih.gov/pubmed/31444371
http://dx.doi.org/10.1038/s41598-019-48300-3

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