Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

Protein misfolding is linked to a wide array of human diseases(1,2). Protective cellular protein quality control (PQC) mechanisms evolved to selectively recognize misfolded proteins and limit their toxic effects(3-9). Here we examine how molecular chaperones and the ubiquitin (Ub)-proteasome system...

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Detalles Bibliográficos
Autores principales: Samant, Rahul S., Livingston, Christine M., Frydman, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707801/
https://www.ncbi.nlm.nih.gov/pubmed/30429547
http://dx.doi.org/10.1038/s41586-018-0678-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707801/
https://www.ncbi.nlm.nih.gov/pubmed/30429547
http://dx.doi.org/10.1038/s41586-018-0678-x

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