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Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
Protein misfolding is linked to a wide array of human diseases(1,2). Protective cellular protein quality control (PQC) mechanisms evolved to selectively recognize misfolded proteins and limit their toxic effects(3-9). Here we examine how molecular chaperones and the ubiquitin (Ub)-proteasome system...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707801/ https://www.ncbi.nlm.nih.gov/pubmed/30429547 http://dx.doi.org/10.1038/s41586-018-0678-x |