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Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
Macrophages are activated during microbial infection to coordinate inflammatory responses and host defense. Here we found that in macrophages activated by bacterial lipopolysaccharide (LPS), mitochondrial glycerol 3-phosphate dehydrogenase (GPD2) regulated glucose oxidation to drive inflammatory res...
Autores principales: | Langston, P. Kent, Nambu, Aya, Jung, Jonathan, Shibata, Munehiko, Aksoylar, H. Ibrahim, Lei, Jiahui, Xu, Peining, Doan, Mary T., Jiang, Helen, MacArthur, Michael R., Gao, Xia, Kong, Yong, Chouchani, Edward T., Locasale, Jason W., Synder, Nathaniel W., Horng, Tiffany |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707851/ https://www.ncbi.nlm.nih.gov/pubmed/31384058 http://dx.doi.org/10.1038/s41590-019-0453-7 |
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