IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

IL-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are I...

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Detalles Bibliográficos
Autores principales: Højen, Jesper Falkesgaard, Vindvad Kristensen, Marie Louise, McKee, Amy S., Wade, Megan Taylor, Azam, Tania, Lunding, Lars P., de Graaf, Dennis M., Swartzwelter, Benjamin J., Wegmann, Michael, Tolstrup, Martin, Beckman, Karsten, Fujita, Mayumi, Fischer, Stephan, Dinarello, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707854/
https://www.ncbi.nlm.nih.gov/pubmed/31427775
http://dx.doi.org/10.1038/s41590-019-0467-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707854/
https://www.ncbi.nlm.nih.gov/pubmed/31427775
http://dx.doi.org/10.1038/s41590-019-0467-1

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