Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI

LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that catalyzes the formation of 2-pyridone natural product leporin C. Biochemical characterization showed LepI can catalyze the stereoselective dehydration to yield a reactive (E)-quinone methide that can undergo bifurcating intramolecular...

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Detalles Bibliográficos
Autores principales: Cai, Yujuan, Hai, Yang, Ohashi, Masao, Jamieson, Cooper S., Garcia-Borras, Marc, Houk, K. N., Zhou, Jiahai, Tang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708486/
https://www.ncbi.nlm.nih.gov/pubmed/31332284
http://dx.doi.org/10.1038/s41557-019-0294-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708486/
https://www.ncbi.nlm.nih.gov/pubmed/31332284
http://dx.doi.org/10.1038/s41557-019-0294-x

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