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Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI

LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that catalyzes the formation of 2-pyridone natural product leporin C. Biochemical characterization showed LepI can catalyze the stereoselective dehydration to yield a reactive (E)-quinone methide that can undergo bifurcating intramolecular...

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Detalles Bibliográficos
Autores principales:	Cai, Yujuan, Hai, Yang, Ohashi, Masao, Jamieson, Cooper S., Garcia-Borras, Marc, Houk, K. N., Zhou, Jiahai, Tang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708486/ https://www.ncbi.nlm.nih.gov/pubmed/31332284 http://dx.doi.org/10.1038/s41557-019-0294-x

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