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Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report

RATIONALE: Atopic dermatitis (AD) is a chronic recurrent dermatitis with profound itching, which could be the first manifestation of acute myeloid leukemia (AML). PATIENT CONCERNS: A 53-year-old Chinese man suffered a 6-month history of systemic symmetrical dermatitis, accompanied with profound itch...

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Autores principales: Ma, Wei-Wei, Kasyanju Carrero, Lorna Martin, Yin, Xu-Feng, Liu, Hou-Fang, Zhou, Bing-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708621/
https://www.ncbi.nlm.nih.gov/pubmed/31393345
http://dx.doi.org/10.1097/MD.0000000000016362
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author Ma, Wei-Wei
Kasyanju Carrero, Lorna Martin
Yin, Xu-Feng
Liu, Hou-Fang
Zhou, Bing-Rong
author_facet Ma, Wei-Wei
Kasyanju Carrero, Lorna Martin
Yin, Xu-Feng
Liu, Hou-Fang
Zhou, Bing-Rong
author_sort Ma, Wei-Wei
collection PubMed
description RATIONALE: Atopic dermatitis (AD) is a chronic recurrent dermatitis with profound itching, which could be the first manifestation of acute myeloid leukemia (AML). PATIENT CONCERNS: A 53-year-old Chinese man suffered a 6-month history of systemic symmetrical dermatitis, accompanied with profound itching. The patient was diagnosed as “eczema” in several hospitals, and the effects of antihistamine and topical steroid creams were poor. Nocturnal sleep was seriously affected by aggravating pruritus. Laboratorial examination was compatible with AML-M4. DIAGNOSES: AML-M4 with AD as first manifestation. INTERVENTIONS: IA regimen (ayninen and cytarabine) were used in induction chemotherapy. However, the patient did not achieve complete remission, and although his rash had improved, he still experienced severely general body itching. On the seventh day of chemotherapy, the patient entered the period of granulocyte deficiency with infection. OUTCOMES: The patient died due to septic shock after chemotherapy. LESSONS: The case strengthens the awareness of AML with AD as first manifestation and raises oncological vigilance in patients with AD refractory.
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spelling pubmed-67086212019-10-01 Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report Ma, Wei-Wei Kasyanju Carrero, Lorna Martin Yin, Xu-Feng Liu, Hou-Fang Zhou, Bing-Rong Medicine (Baltimore) Research Article RATIONALE: Atopic dermatitis (AD) is a chronic recurrent dermatitis with profound itching, which could be the first manifestation of acute myeloid leukemia (AML). PATIENT CONCERNS: A 53-year-old Chinese man suffered a 6-month history of systemic symmetrical dermatitis, accompanied with profound itching. The patient was diagnosed as “eczema” in several hospitals, and the effects of antihistamine and topical steroid creams were poor. Nocturnal sleep was seriously affected by aggravating pruritus. Laboratorial examination was compatible with AML-M4. DIAGNOSES: AML-M4 with AD as first manifestation. INTERVENTIONS: IA regimen (ayninen and cytarabine) were used in induction chemotherapy. However, the patient did not achieve complete remission, and although his rash had improved, he still experienced severely general body itching. On the seventh day of chemotherapy, the patient entered the period of granulocyte deficiency with infection. OUTCOMES: The patient died due to septic shock after chemotherapy. LESSONS: The case strengthens the awareness of AML with AD as first manifestation and raises oncological vigilance in patients with AD refractory. Wolters Kluwer Health 2019-08-09 /pmc/articles/PMC6708621/ /pubmed/31393345 http://dx.doi.org/10.1097/MD.0000000000016362 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Ma, Wei-Wei
Kasyanju Carrero, Lorna Martin
Yin, Xu-Feng
Liu, Hou-Fang
Zhou, Bing-Rong
Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report
title Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report
title_full Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report
title_fullStr Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report
title_full_unstemmed Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report
title_short Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report
title_sort acute myeloid leukemia with adult atopic dermatitis as first manifestation: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708621/
https://www.ncbi.nlm.nih.gov/pubmed/31393345
http://dx.doi.org/10.1097/MD.0000000000016362
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