Comparison of oxcarbazepine efficacy and MHD concentrations relative to age and BMI: Associations among ABCB1, ABCC2, UGT2B7, and SCN2A polymorphisms

Genetic polymorphisms are related to the concentration and efficacy of oxcarbazepine (OXC). 10-Hydroxycarbazepine (MHD) is the major pharmacologically active metabolite of OXC, and it exerts an antiepileptic effect. This study aimed to explore the connection between the MHD concentration and genes s...

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Detalles Bibliográficos
Autores principales: Yang, Xue, Yan, Yuanliang, Fang, Shu, Zeng, Shuangshuang, Ma, Hongying, Qian, Long, Chen, Xi, Wei, Jie, Gong, Zhicheng, Xu, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708905/
https://www.ncbi.nlm.nih.gov/pubmed/30896644
http://dx.doi.org/10.1097/MD.0000000000014908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708905/
https://www.ncbi.nlm.nih.gov/pubmed/30896644
http://dx.doi.org/10.1097/MD.0000000000014908

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