A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype

In adult patients after living‐donor liver transplantation, postoperative days and the cytochrome P450 3A5 (CYP3A5) genotype are known to affect tacrolimus pharmacokinetics. In this study, we constructed a physiologically‐based pharmacokinetic model adapted to the clinical data and evaluated the con...

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Detalles Bibliográficos
Autores principales: Itohara, Kotaro, Yano, Ikuko, Tsuzuki, Tetsunori, Uesugi, Miwa, Nakagawa, Shunsaku, Yonezawa, Atsushi, Okajima, Hideaki, Kaido, Toshimi, Uemoto, Shinji, Matsubara, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709420/
https://www.ncbi.nlm.nih.gov/pubmed/31087501
http://dx.doi.org/10.1002/psp4.12420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709420/
https://www.ncbi.nlm.nih.gov/pubmed/31087501
http://dx.doi.org/10.1002/psp4.12420

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