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Time‐to‐Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine‐Citrulline‐Monomethylauristatin E Antibody–Drug Conjugates

Peripheral neuropathy (PN) is a common long‐term debilitating toxicity of antimicrotubule agents. PN was the most frequent adverse event resulting in dose modifications and/or discontinuation of treatment for valine‐citrulline‐monomethylauristatin E antibody–drug conjugates (ADCs) developed at Genen...

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Detalles Bibliográficos
Autores principales: Kågedal, Matts, Samineni, Divya, Gillespie, William R., Lu, Dan, Fine, Bernard M., Girish, Sandhya, Li, Chunze, Jin, Jin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709423/
https://www.ncbi.nlm.nih.gov/pubmed/31207190
http://dx.doi.org/10.1002/psp4.12442