Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan

We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in r...

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Detalles Bibliográficos
Autores principales: Ghodousi, Arash, Rizvi, Alamdar Hussain, Baloch, Aurangzaib Quadir, Ghafoor, Abdul, Khanzada, Faisal Masood, Qadir, Mehmood, Borroni, Emanuele, Trovato, Alberto, Tahseen, Sabira, Cirillo, Daniela Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709449/
https://www.ncbi.nlm.nih.gov/pubmed/31262765
http://dx.doi.org/10.1128/AAC.00915-19
Descripción
Sumario:We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment. This study underlines the relevance of surveillance programs following the introduction of new drugs.

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