Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan

We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in r...

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Autores principales: Ghodousi, Arash, Rizvi, Alamdar Hussain, Baloch, Aurangzaib Quadir, Ghafoor, Abdul, Khanzada, Faisal Masood, Qadir, Mehmood, Borroni, Emanuele, Trovato, Alberto, Tahseen, Sabira, Cirillo, Daniela Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709449/
https://www.ncbi.nlm.nih.gov/pubmed/31262765
http://dx.doi.org/10.1128/AAC.00915-19
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author Ghodousi, Arash
Rizvi, Alamdar Hussain
Baloch, Aurangzaib Quadir
Ghafoor, Abdul
Khanzada, Faisal Masood
Qadir, Mehmood
Borroni, Emanuele
Trovato, Alberto
Tahseen, Sabira
Cirillo, Daniela Maria
author_facet Ghodousi, Arash
Rizvi, Alamdar Hussain
Baloch, Aurangzaib Quadir
Ghafoor, Abdul
Khanzada, Faisal Masood
Qadir, Mehmood
Borroni, Emanuele
Trovato, Alberto
Tahseen, Sabira
Cirillo, Daniela Maria
author_sort Ghodousi, Arash
collection PubMed
description We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment. This study underlines the relevance of surveillance programs following the introduction of new drugs.
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spelling pubmed-67094492019-09-11 Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan Ghodousi, Arash Rizvi, Alamdar Hussain Baloch, Aurangzaib Quadir Ghafoor, Abdul Khanzada, Faisal Masood Qadir, Mehmood Borroni, Emanuele Trovato, Alberto Tahseen, Sabira Cirillo, Daniela Maria Antimicrob Agents Chemother Mechanisms of Resistance We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment. This study underlines the relevance of surveillance programs following the introduction of new drugs. American Society for Microbiology 2019-08-23 /pmc/articles/PMC6709449/ /pubmed/31262765 http://dx.doi.org/10.1128/AAC.00915-19 Text en Copyright © 2019 Ghodousi et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Ghodousi, Arash
Rizvi, Alamdar Hussain
Baloch, Aurangzaib Quadir
Ghafoor, Abdul
Khanzada, Faisal Masood
Qadir, Mehmood
Borroni, Emanuele
Trovato, Alberto
Tahseen, Sabira
Cirillo, Daniela Maria
Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
title Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
title_full Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
title_fullStr Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
title_full_unstemmed Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
title_short Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
title_sort acquisition of cross-resistance to bedaquiline and clofazimine following treatment for tuberculosis in pakistan
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709449/
https://www.ncbi.nlm.nih.gov/pubmed/31262765
http://dx.doi.org/10.1128/AAC.00915-19
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