Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects

SPR741 is a novel polymyxin B derivative, with minimal intrinsic antibacterial activity and reduced nonclinical nephrotoxicity compared to levels with polymyxin B, that interacts with the outer membrane of Gram-negative bacteria, enhancing penetration of coadministered antibiotics. The safety, toler...

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Detalles Bibliográficos
Autores principales: Eckburg, Paul B., Lister, Troy, Walpole, Susannah, Keutzer, Tim, Utley, Luke, Tomayko, John, Kopp, Ellen, Farinola, Nicholas, Coleman, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709486/
https://www.ncbi.nlm.nih.gov/pubmed/31262767
http://dx.doi.org/10.1128/AAC.00892-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709486/
https://www.ncbi.nlm.nih.gov/pubmed/31262767
http://dx.doi.org/10.1128/AAC.00892-19

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