Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic trafficking of immune cells. In cancer, CCR7-mediated trafficking leads to lymph node metastasis, suggesting the receptor as a promising therapeutic target. Here, we present the crystal structure of human CCR7 fused to...

Descripción completa

Detalles Bibliográficos
Autores principales: Jaeger, Kathrin, Bruenle, Steffen, Weinert, Tobias, Guba, Wolfgang, Muehle, Jonas, Miyazaki, Takuya, Weber, Martin, Furrer, Antonia, Haenggi, Noemi, Tetaz, Tim, Huang, Chia-Ying, Mattle, Daniel, Vonach, Jean-Marie, Gast, Alain, Kuglstatter, Andreas, Rudolph, Markus G., Nogly, Przemyslaw, Benz, Joerg, Dawson, Roger J.P., Standfuss, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709783/
https://www.ncbi.nlm.nih.gov/pubmed/31442409
http://dx.doi.org/10.1016/j.cell.2019.07.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709783/
https://www.ncbi.nlm.nih.gov/pubmed/31442409
http://dx.doi.org/10.1016/j.cell.2019.07.028

Ejemplares similares