Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet

BACKGROUND: A combination of olanzapine and samidorphan (OLZ/SAM) is in development to provide the established antipsychotic efficacy of olanzapine while mitigating olanzapine-induced weight gain. METHODS: Two multicenter, open-label, parallel-cohort studies were performed to evaluate the effect of...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Yagoda, Sergey, Du, Yangchun, von Moltke, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709789/
https://www.ncbi.nlm.nih.gov/pubmed/31686778
http://dx.doi.org/10.2147/DDDT.S205000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709789/
https://www.ncbi.nlm.nih.gov/pubmed/31686778
http://dx.doi.org/10.2147/DDDT.S205000

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