Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria

Transcriptional regulation by nuclease-deficient CRISPR/Cas is a popular and valuable tool for routine control of gene expression. CRISPR interference in bacteria can be reliably achieved with high efficiencies. Yet, options for CRISPR activation (CRISPRa) remained limited in flexibility and activit...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Wan, Xinyi, Wang, Baojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710252/
https://www.ncbi.nlm.nih.gov/pubmed/31451697
http://dx.doi.org/10.1038/s41467-019-11479-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710252/
https://www.ncbi.nlm.nih.gov/pubmed/31451697
http://dx.doi.org/10.1038/s41467-019-11479-0

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