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Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
Transcriptional regulation by nuclease-deficient CRISPR/Cas is a popular and valuable tool for routine control of gene expression. CRISPR interference in bacteria can be reliably achieved with high efficiencies. Yet, options for CRISPR activation (CRISPRa) remained limited in flexibility and activit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710252/ https://www.ncbi.nlm.nih.gov/pubmed/31451697 http://dx.doi.org/10.1038/s41467-019-11479-0 |