Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM). Gain-of-function mutations in the tyrosine kinase receptor TIE2 can cause VM and induce a ligand-i...

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Detalles Bibliográficos
Autores principales: Cai, Yuqi, Schrenk, Sandra, Goines, Jillian, Davis, George E., Boscolo, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710257/
https://www.ncbi.nlm.nih.gov/pubmed/31451744
http://dx.doi.org/10.1038/s41598-019-48854-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710257/
https://www.ncbi.nlm.nih.gov/pubmed/31451744
http://dx.doi.org/10.1038/s41598-019-48854-2

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