Inhibition of Glyoxalase-I Leads to Reduced Proliferation, Migration and Colony Formation, and Enhanced Susceptibility to Sorafenib in Hepatocellular Carcinoma

Background: Glyoxalase-I (Glo-I) is essential for detoxification of methylglyoxal (MGO), a byproduct of glycolysis. Overexpression of Glo-I has been linked to multi-drug resistance in cancer therapy. The aim of this study was to analyze Glo-I in hepatocellular carcinoma (HCC) and the effect of the m...

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Detalles Bibliográficos
Autores principales: Michel, Maurice, Hollenbach, Marcus, Pohl, Sabine, Ripoll, Cristina, Zipprich, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710403/
https://www.ncbi.nlm.nih.gov/pubmed/31482070
http://dx.doi.org/10.3389/fonc.2019.00785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710403/
https://www.ncbi.nlm.nih.gov/pubmed/31482070
http://dx.doi.org/10.3389/fonc.2019.00785

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