LL-37 Exacerbates Local Inflammation in Sepsis-Induced Acute Lung Injury by Preventing Mitochondrial DNA (mtDNA) Degradation-Induced Autophagy

BACKGROUND: Recent studies have proved that autophagy dysfunction in proinflammatory cells is involved in tissue damage and an excessive inflammatory response in sepsis. In the present study, we identified that the human antimicrobial peptide LL-37 facilitates resistance to DNase II-induced mitochon...

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Detalles Bibliográficos
Autores principales: Zuo, Yunlong, Dang, Run, Peng, Hongyan, Wu, Zhiyuan, Yang, Yiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711262/
https://www.ncbi.nlm.nih.gov/pubmed/31422413
http://dx.doi.org/10.12659/MSM.915298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711262/
https://www.ncbi.nlm.nih.gov/pubmed/31422413
http://dx.doi.org/10.12659/MSM.915298

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