Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAF(V600E) oncoprotein kinase

Human lung adenocarcinoma exhibits a propensity for de-differentiation, complicating diagnosis and treatment, and predicting poorer patient survival. In genetically engineered mouse models of lung cancer, expression of the BRAF(V600E) oncoprotein kinase initiates the growth of benign tumors retainin...

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Detalles Bibliográficos
Autores principales: van Veen, J Edward, Scherzer, Michael, Boshuizen, Julia, Chu, Mollee, Liu, Annie, Landman, Allison, Green, Shon, Trejo, Christy, McMahon, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711745/
https://www.ncbi.nlm.nih.gov/pubmed/31452510
http://dx.doi.org/10.7554/eLife.43668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711745/
https://www.ncbi.nlm.nih.gov/pubmed/31452510
http://dx.doi.org/10.7554/eLife.43668

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