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Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer

Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency....

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Detalles Bibliográficos
Autores principales: Yu, Lili, Ji, Kai-yuan, Zhang, Jian, Xu, Yanxia, Ying, Yue, Mai, Taoyi, Xu, Shuxiang, Zhang, Qian-bing, Yao, Kai-tai, Xu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711954/
https://www.ncbi.nlm.nih.gov/pubmed/31152430
http://dx.doi.org/10.1007/s13238-019-0637-9