Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

Nonribosomal peptide synthetases (NRPSs) underlie the biosynthesis of many natural products that have important medicinal utility. Protection of the NRPS peptide products from proteolysis is critical to these pathways and is often achieved by structural modification, principally the introduction of...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Ketan D., d’Andrea, Felipe B., Gaudelli, Nicole M., Buller, Andrew R., Townsend, Craig A., Gulick, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711958/
https://www.ncbi.nlm.nih.gov/pubmed/31455765
http://dx.doi.org/10.1038/s41467-019-11740-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711958/
https://www.ncbi.nlm.nih.gov/pubmed/31455765
http://dx.doi.org/10.1038/s41467-019-11740-6

Ejemplares similares