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Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

The maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regeneration. Little is known about how adult stem cells respond to irreversible DNA damage, resulting in loss of regeneration in humans. Here, we establish a permanent regeneration loss model using cycling hum...

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Detalles Bibliográficos
Autores principales: Kim, Jin Yong, Ohn, Jungyoon, Yoon, Ji-Seon, Kang, Bo Mi, Park, Minji, Kim, Sookyung, Lee, Woochan, Hwang, Sungjoo, Kim, Jong-Il, Kim, Kyu Han, Kwon, Ohsang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711970/
https://www.ncbi.nlm.nih.gov/pubmed/31455775
http://dx.doi.org/10.1038/s41467-019-11665-0