Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism

Hailey-Hailey disease is an autosomal genetic disease caused by mutations in one of the two ATP2C1 alleles encoding the secretory pathway Ca(2+)/Mn(2+)-ATPase, hSPCA1. The disease almost exclusively affects epidermis, where it mainly results in acantholysis of the suprabasal layers. The etiology of...

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Detalles Bibliográficos
Autores principales: Muncanovic, Daniel, Justesen, Mette Heberg, Preisler, Sarah Spruce, Pedersen, Per Amstrup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712213/
https://www.ncbi.nlm.nih.gov/pubmed/31455819
http://dx.doi.org/10.1038/s41598-019-48866-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712213/
https://www.ncbi.nlm.nih.gov/pubmed/31455819
http://dx.doi.org/10.1038/s41598-019-48866-y

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