Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice

ADAM17, prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Several of these play central roles in oncogenesis and inflammation, yet despite its importance, the mechanism by which ADAM17 is activat...

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Detalles Bibliográficos
Autores principales: Veit, Martin, Ahrens, Björn, Seidel, Jana, Sommer, Anselm, Bhakdi, Sucharit, Reiss, Karina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712283/
https://www.ncbi.nlm.nih.gov/pubmed/31455669
http://dx.doi.org/10.26508/lsa.201900430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712283/
https://www.ncbi.nlm.nih.gov/pubmed/31455669
http://dx.doi.org/10.26508/lsa.201900430

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