Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

BACKGROUND: The activity of MP1, a pyrrolomycin, was studied in MYCN amplified neuroblastoma (NB) alone and combined with temsirolimus (TEM). METHODS: Activity of MP1 was tested in MYCN amplified (BE-2c, IMR) and non amplified (SKN-AS) NB cells. The effect of MP1 on MYCN, MCL-1, cleaved PARP, LC3II/...

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Detalles Bibliográficos
Autores principales: McGuire, Timothy R., Coulter, Don W., Bai, Dachang, Sughroue, Jason A., Li, Jerry, Yang, Zunhua, Qiao, Zhen, Liu, Yan, Murry, Daryl J., Chhonker, Yashpal S., McIntyre, Erin M., Alexander, Gracey, Sharp, John G., Li, Rongshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712804/
https://www.ncbi.nlm.nih.gov/pubmed/31455317
http://dx.doi.org/10.1186/s12885-019-6033-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712804/
https://www.ncbi.nlm.nih.gov/pubmed/31455317
http://dx.doi.org/10.1186/s12885-019-6033-2

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