Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional...

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Detalles Bibliográficos
Autores principales: Rotondi, Giulia, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, De Monte, Celeste, De Filippis, Barbara, Maccallini, Cristina, Amoroso, Rosa, Cirilli, Roberto, Akdemir, Atilla, Angeli, Andrea, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713143/
https://www.ncbi.nlm.nih.gov/pubmed/31401897
http://dx.doi.org/10.1080/14756366.2019.1651315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713143/
https://www.ncbi.nlm.nih.gov/pubmed/31401897
http://dx.doi.org/10.1080/14756366.2019.1651315

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