Cargando…

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rotondi, Giulia, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, De Monte, Celeste, De Filippis, Barbara, Maccallini, Cristina, Amoroso, Rosa, Cirilli, Roberto, Akdemir, Atilla, Angeli, Andrea, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713143/ https://www.ncbi.nlm.nih.gov/pubmed/31401897 http://dx.doi.org/10.1080/14756366.2019.1651315

Ejemplares similares

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2019)

Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation
por: Guglielmi, Paolo, et al.
Publicado: (2020)

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms
por: D’Ascenzio, Melissa, et al.
Publicado: (2016)

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors
por: Güzel-Akdemir, Özlen, et al.
Publicado: (2020)

Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators
por: Mollica, Adriano, et al.
Publicado: (2017)

Heterocyclic amines (HCAS) and risk of breast cancer
por: Sinha, R, et al.
Publicado: (2001)

New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study
por: Maccallini, Cristina, et al.
Publicado: (2021)

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors
por: Güzel-Akdemir, Özlen, et al.
Publicado: (2018)

Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae
por: Demir-Yazıcı, Kübra, et al.
Publicado: (2020)

Nitric Oxide Donors and Selective Carbonic Anhydrase Inhibitors: A Dual Pharmacological Approach for the Treatment of Glaucoma, Cancer and Osteoporosis
por: Carradori, Simone, et al.
Publicado: (2015)

Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase
por: Sadutto, Daniele, et al.
Publicado: (2023)

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
por: Guglielmi, Paolo, et al.
Publicado: (2019)

Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives
por: Carradori, Simone, et al.
Publicado: (2017)

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme
por: Akdemir, Atilla, et al.
Publicado: (2019)

Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies
por: Pontecorvi, Virginia, et al.
Publicado: (2022)

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
por: Gumus, Arzu, et al.
Publicado: (2022)

Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies
por: Ferraroni, Marta, et al.
Publicado: (2022)

Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents
por: Zengin Kurt, Belma, et al.
Publicado: (2023)

Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII
por: Demir-Yazıcı, Kübra, et al.
Publicado: (2019)

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
por: Angeli, Andrea, et al.
Publicado: (2020)

Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis
por: Chiavarini, Manuela, et al.
Publicado: (2017)

Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies
por: Carradori, Simone, et al.
Publicado: (2022)

Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators
por: Angeli, Andrea, et al.
Publicado: (2021)

Dual Carbonic Anhydrase IX/XII Inhibitors and Carbon Monoxide Releasing Molecules Modulate LPS-Mediated Inflammation in Mouse Macrophages
por: Berrino, Emanuela, et al.
Publicado: (2021)

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?
por: Carradori, Simone, et al.
Publicado: (2022)

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
por: Angeli, Andrea, et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2021)

HDAC Inhibitors for the Therapy of Triple Negative Breast Cancer
por: Maccallini, Cristina, et al.
Publicado: (2022)

Sulfonamide inhibition studies of two β-carbonic anhydrases from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2
por: Vullo, Daniela, et al.
Publicado: (2018)

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
por: Nocentini, Alessio, et al.
Publicado: (2021)

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity
por: Guglielmi, Paolo, et al.
Publicado: (2019)

Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors
por: Swain, Baijayantimala, et al.
Publicado: (2022)

Photoactivatable Heptamethine-Based Carbonic Anhydrase Inhibitors Leading to New Anti-Antibacterial Agents
por: Carradori, Simone, et al.
Publicado: (2023)

Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents
por: Veschi, Serena, et al.
Publicado: (2020)

Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders
por: Maccallini, Cristina, et al.
Publicado: (2016)

Preface to Nitric Oxide Modulators in Health and Disease I
por: Maccallini, Cristina, et al.
Publicado: (2022)

Neuronal Nitric Oxide Synthase and Post-Translational Modifications in the Development of Central Nervous System Diseases: Implications and Regulation
por: Maccallini, Cristina, et al.
Publicado: (2023)

Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_71r04u3duguhi2ituv7gh8mo6d