Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi

Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate syn...

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Detalles Bibliográficos
Autores principales: Teixeira, Bárbara Velame Ferreira, Teles, André Lacerda Braga, da Silva, Suellen Gonçalves, Brito, Camila Carane Bitencourt, de Freitas, Humberto Fonseca, Pires, Acássia Benjamim Leal, Froes, Thamires Quadros, Castilho, Marcelo Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713189/
https://www.ncbi.nlm.nih.gov/pubmed/31409157
http://dx.doi.org/10.1080/14756366.2019.1651311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713189/
https://www.ncbi.nlm.nih.gov/pubmed/31409157
http://dx.doi.org/10.1080/14756366.2019.1651311

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