TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion

Exhausted CD8(+) T cells (T(EX)) in chronic infections and cancer have limited effector function, high inhibitory receptor co-expression and extensive transcriptional changes compared to effector (T(EFF)) or memory (T(MEM)) CD8(+) T cells. T(EX) are important clinical targets of checkpoint blockade...

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Detalles Bibliográficos
Autores principales: Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713202/
https://www.ncbi.nlm.nih.gov/pubmed/31207603
http://dx.doi.org/10.1038/s41586-019-1325-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713202/
https://www.ncbi.nlm.nih.gov/pubmed/31207603
http://dx.doi.org/10.1038/s41586-019-1325-x

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