Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity

MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute to the aetiology of the AD. Thus, both iron ion chelators and MAO-B inhibitors can be used to treat AD. Taking the coumarin derivatives and hydroxypyridinones as the lead compounds, a series o...

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Detalles Bibliográficos
Autores principales: Mi, Zhisheng, Gan, Bing, Yu, Sihang, Guo, Jianan, Zhang, Changjun, Jiang, Xiaoying, Zhou, Tao, Su, Jing, Bai, Renren, Xie, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713216/
https://www.ncbi.nlm.nih.gov/pubmed/31416364
http://dx.doi.org/10.1080/14756366.2019.1634703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713216/
https://www.ncbi.nlm.nih.gov/pubmed/31416364
http://dx.doi.org/10.1080/14756366.2019.1634703

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