Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity

[Image: see text] Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for NNMT as a potential therapeu...

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Detalles Bibliográficos
Autores principales: Gao, Yongzhi, van Haren, Matthijs J., Moret, Ed E., Rood, Johannes J. M., Sartini, Davide, Salvucci, Alessia, Emanuelli, Monica, Craveur, Pierrick, Babault, Nicolas, Jin, Jian, Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713424/
https://www.ncbi.nlm.nih.gov/pubmed/31265285
http://dx.doi.org/10.1021/acs.jmedchem.9b00413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713424/
https://www.ncbi.nlm.nih.gov/pubmed/31265285
http://dx.doi.org/10.1021/acs.jmedchem.9b00413

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